The effects of whole-body cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzymes in multiple sclerosis patients

Oxidative stress is an important factor which contribute to the pathogenesis of lesions in multiple sclerosis (MS). Whole body cryotherapy (WBCT) is often used in treatment neurological and orthopedic diseases.

THE AIM, MATERIAL AND METHODS: The aim of this study was to determinate the level of total antioxidative status (TAS) in plasma and activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes of MS patients (n = 28) before and after 10 exposures of WBCT (-120 degrees C/3 minutes/day). 16 MS patients during 10 exposures of WBCT additionally were supplemented by 10 mg of melatonin.

RESULTS: Increasing of TAS level in plasma as well as supplemented with melatonin and non-supplemented MS patients was observed after 10 exposures of WBCT Melatonin statistically significant increased activity of SOD and CAT in erythrocytes of MS patients treated with WBCT.

CONCLUSIONS: Results of our study indicate significant increase of TAS level in plasma of MS patients of WBCT treatment. This indicate that WBCT might be a therapy which suppress oxidative stress in MS patients.


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Influence of the ten sessions of the whole body cryostimulation on aerobic and anaerobic capacity

OBJECTIVES: The aim of this study was to determine the influence of whole body cryostmulation on aerobic and anaerobic capacities.

MATERIALS AND METHODS: To test the hypothesis that whole body cryostimulation improves physical capacity, thirty subjects (fifteen males and fifteen females) undertook two ergocycle trials before and after the ten sessions of cryogenic chamber treatment. To assess baseline aerobic capacity. the progressive cycle ergometer test was applied This allowed determination of maximal oxygen uptake and ventilatory thresholds. Twenty-second Wingate test was performed to assess baseline levels of anaerobic power. After finishing the treatments in the cryogenic chamber the exercise protocol was repeated. Before the first. and after the last whole body cryostimulation. venous blood samples were drawn to determine basic blood values. including levels of erythrocytes. leukocytes and thrombocytes hemoglobin concentration and hematocrit.

RESULTS: There were no changes in aerobic capacity in both females and males. after ten sessions of 3-minute-long exposures to cryogenic temperature (-130 degrees CI Participation in the whole body cryostimulation caused an increase in maximal anaerobic power in males (from 11.1 to 11 9 W x kg(-1j P < 0.05) but not in females

CONCLUSIONS: It can be concluded that whole body cryostimulation can be beneficial at least in males. for increasing anaerobic capacity in sport disciplines involving speed and strength



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Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis.

INTRODUCTION: Conventional physiotherapy (electrotherapy. magnetic fields). kinesitherapy, and whole-body cryotherapy (plus kinesitherapy) are used to relieve pain and inflammation or to improve function in rheumatic diseases. The aim of this study was to investigate the effects of different physiotherapies and cryotherapy on biochemical blood parameters of patients with rheumatoid arthritis (RA) and osteoarthritis (OA).

MATERIALS AND METHODS: Twenty patients with RA and 17 patients with OA received whole-body cryotherapy at -140 to -160 degrees C for 2 to 3 min, once daily for 4 weeks. The second group of patients (24 with RA and 28 with OA) received conventional physiotherapy for 4 weeks. We measured the parameters of neutrophil activation (respiratory burst. calprotectin) and markers of cartilage metabolism (N-acetyl­beta-D-hexosaminidase (NAHase), ectonucleotide pyrophosphohydrolase (NTPPHase)) twice: before and 3 months after cryotherapy or physiotherapy.

RESULTS: We showed. for the first time, that cryotherapy significantly reduced (P < 0.001) histamine levels in the blood of patients with RA. The effect was long-lasting (for at least 3 months). The levels of blood histamine in patients with OA were not changed significantly. Cryotherapy also downregulated the respiratory burst of PMNs and NAHase activity and upregulated calprotectin levels and the activity of NTPPHase. However, these changes were not statistically significant. In contrast, there were no significant changes in histamine levels or the other biochemical parameters measured in groups of patients treated only with physiotherapy and kinesitherapy.

CONCLUSION: It may be concluded that the beneficial clinical effects of cryotherapy in RA patients are in pad due to the action on the production, release. or degradation of histamine.


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Does whole body cryotherapy sessions of have influence on white blood cell count, level of IL6 and total oxidative and antioxidative status in healthy men?

The influence of extremely low temperatures on the human body and physiological reactions are not fully recognized. It has been postulated that cryotherapy could modify immunological reactions, leukocytes mobilization and levels of cytokines. The aim of this research was to estimate the influence of a ten sessions 3-min-long exposures to cryogenic temperature (-130 degrees C) on the white blood cell (WBC) count, level of IL6 and the total oxidative and antioxidative status in 15 young, clinically healthy men. Blood samples were obtained in the morning before cryotherapy, again 30 min after treatment and the next day in the morning, both during the first and tenth session. The WBC count, level of IL6 and total lipid peroxides as the total oxidative status and the total antioxidative status (TAS), were measured. After completing a total of ten whole-body therapy sessions a significant increase in WBC count, especially lymphocytes and monocytes was noted. There was an increase in level of IL6 after first and the last cryotherapy the most pronounced after tenth session. On the contrary the TAS level decreased significant after the treatment. It was concluded that repeated expositions to extremely low temperatures use in cryotherapy have mobilization effect on immunological system.


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Whole-body cryotherapy in patients with inflammatory rheumatic disease. A prospective study

BACKGROUND: As yet, whole-body cryotherapy is especially used for the therapy of chronic inflammatory arthritis. An analgetic effect has been described in several studies. However, only few data exist concerning the long-term effects of this therapy.

PATIENTS AND METHODS: A total of 60 patients with rheumatoid arthritis (n • 48), and ankylosing spondylitis (n • 12) was analyzed. Patients underwent treatment with whole-body cryotherapy twice a day. The average age was 55.7 +1- 10.33. The study group consisted of 48 female and twelve male patients. The average number of therapeutic treatments with cryotherapy was 15.8 +1- 8.37, the average follow-up 63.4 +1- 63.48 days.

RESULTS: 13 patients (21.7%) discontinued treatment because of adverse effects. For patients with rheumatoid arthritis, DAS28 (Disease Activity Score) and VAS (visual analog scale) were determined. A significant reduction of both parameters was found (DAS 3.9 +1- 1.22 vs. 3.4 +1- 1.08: p < 0.01: VAS 51.4 +1- 16.62 vs. 37.9 +1- 19.13: p < 0.01). BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) was analyzed for patients with ankylosing spondylitis, and also showed a significant reduction (4.4 +1- 1.91 vs. 3.1 +1- 1.34: p • 0.01).

CONCLUSION: Thus, whole-body cryotherapy is an effective option in the concept of treatment of inflammatory rheumatic diseases. The relief of pain allows an intensification of physiotherapy. A significant reduction of pain over a period of 2 months could be shown.


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Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders.

INTRODUCTION: Rheumatism has been treated using whole-body cryotherapy (WBCT) since the 1970s. The aim of this study was to assess the efficacy of WBCT as an experimental, adjunctive method of treating depressive and anxiety disorders.

MATERIALS AND METHODS: A control (n=34) and a study group (n=26), both consisting of outpatients 18-65 years old with depressive and anxiety disorders (ICD-10), received standard psychopharmacotherapy. The study group was additionally treated with a series of 15 daily visits to a cryogenic chamber (2-3 min. from -160 degrees C to -110 degrees C). The Hamilton’s depression rating scale (HORS) and Hamilton’s anxiety rating scale (HARS) were used as the outcome measures.

RESULTS: After three weeks, a decrease of at least 50% from the baseline HDRS-17 scores in 34.6% of the study group and 2.9% of the control group and a decrease of at least 50% from the baseline HARS score in 46.2% of the study group and in none of the control group were noted.

CONCLUSIONS: These findings, despite such limitations as a small sample size, suggest a possible role for WBCT as a short-term adjuvant treatment for mood and anxiety disorders.


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Influence of whole body cryotherapy on depressive symptoms – preliminary report.

BACKGROUND: Cryotherapy has a long tradition in somatic medicine. Yet we know very little about its impact on psyche and mood disturbances in particular. Therefore there is a real need for scientific investigations into this problem.

OBJECTIVE: The study reported here was an initial approach to whole-body cryotherapy (WBCT) as a potential treatment modality for depression and was expected to provide rough data helping to design a future project with extended methodology, larger sample groups and longer follow-up.

METHODS: Twenty-three patients aged 37-70 years gave informed consent to participate in the study. Ten WBCT procedures (160 s. -150°C) were applied within 2 weeks. Participants were recruited from depressed day hospital patients. Antidepressive medication was not ceased. Symptoms were rated at the beginning and end of this intervention using the 21-item Hamilton Depression Rating Scale (HDRS). Changes in scores were analyzed in the group of patients for every item separately as well as for the sum of all items for each patient.

RESULTS: Almost for each individual HDRS item, the overall score for all patients together was significantly lower after WBCT. This means that all symptoms, except for day-night mood fluctuations, were presumably positively influenced by cryotherapy. The HORS sum-score for each patient after WBCT was lower than that of the baseline and reached statistical significance in a paired samples t-test. Every patient was therefore considerably relieved after WBCT.

CONCLUSIONS: It appears that WBCT helps in alleviating depression symptoms. Should this be confirmed in the extended study we are currently implementing. WBCT may become an auxiliary treatment in depression.


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5 Potential Benefits of Cryotherapy, Including Pain Relief

More than 550,000 whole-body cryotherapy sessions have been performed around the world since 2011. Cryotherapy has become an increasingly trendy “therapy” in recent years in the alternative healthcare space. Even well-known celebrities and athletes, like LeBron James and Shaquille O’Neal, have reported using cryotherapy to support exercise recovery and performance.

While cryotherapy might seem like a novel and exciting concept, the use of very cold temperatures to reduce pain, support healing and elevate moods is actually nothing new. People all over the world have used cold packs and ice baths to promote healing for hundreds of years.

What are the health benefits of cryotherapy (also called whole-body cryotherapy or simply WBC) according to the latest research? There’s some evidence that cryotherapy has anti-inflammatory, anti-analgesic, and antioxidant effects. However study results have been mixed overall, since not every study has found that cryotherapy is any better than rest and stretching for decreasing symptoms like muscle, bone and joint pain, fatigue and soreness.

It’s important to point out that the Food and Drug Administration (FDA) does not currently regulate the use of cryotherapy offered by“cryotherapists” at cryotherapy centers, nor does it recognize any of its medical benefits. This means that if you do choose to try cryotherapy, be aware that there are some potential risks involved.

What Is Cryotherapy?

Cryotherapy is a type of treatment that involves exposure to extremely cold air. One definition of cryotherapy is “A technique that uses an extremely cold liquid or instrument to freeze and destroy abnormal skin cells that require removal.”  The extreme cold comes from liquid nitrogen or argon gas.

What is the point of cryotherapy?

  • Reduced inflammation
  • Help with pain reduction and relieving muscle soreness
  • Improved recovery from exercise injuries, impact or trauma
  • Mood enhancement
  • Increases in energy
  • Help with weight loss and fat-burning
  • Reductions in symptoms of osteoarthritis, osteoporosis, multiple sclerosis and rheumatoid arthritis
  • Decreased asthma symptoms
  • Increased libido

Even though it’s possible that some may experience improvements in their health following cryotherapy session, this has not been proven in many studies and is still widely disputed by some experts. In fact, according to a 2015 Cochrane review that included results from four laboratory-based randomised controlled trials that focused on the effects of whole-body cryotherapy, there is “insufficient evidence” that cryotherapy helps to treat symptoms like pain and soreness.

The same review stated that studies included has also not been able to show that cryotherapy does in fact improve recovery times in athletes when compared with rest.  On a positive note, the Cochrane review did found that in one study participants reported improved “well-being” and less tiredness after cryotherapy following exercise. They also found there were no reports of adverse events in any of the four studies.

On the other hand, another 2017 review published in the International Journal of Sports Medicine found the opposite to be true: cryotherapy did help to reduce soreness and improve recovery in athletes (more on this below).

How does whole-body cryotherapy (WBC) work? What does cryotherapy do to your body?

  • Cryotherapy is believed to work by reducing inflammatory processes, improving blood flow, and releasing feel-good endorphins.
  • “Whole-body cryotherapy” involves a single or repeated exposure to extremely cold, dry air inside a special chamber or cabin.
  • A cryotherapy chamber is an upright cylindrical capsule. It is padded on the inside of the chamber and closed around most of your body, but the top of the chamber remains open so your head stays out.
  • From your neck down, very cold gas surrounds your body which is released from the chamber. Inside the cryotherapy chamber it gets extremely cold, typically around minus 100 degrees Fahrenheit — and in some cases down to a low temperature of minus 300 degrees.
  • Staff workers set machines that control how cold the cryotherapy temperature will get and how long the session lasts. Once the chamber reaches a low temp (such as minus 100–300 degrees Fahrenheit) this will be sustained for only about 2-5 minutes.
  • Inside the chamber you wear minimal clothing, usually gloves, a woolen headband covering the ears, a nose and mouth mask, dry shoes and socks, and boxers for men. This helps to reduce the risk of cold-related injury.
  • Staff worker stand next to the chamber while you stand inside. From the inside you can push the door open if you feel you want to end the session before the expected time.
  • If you’re doing WBC to help with exercise recovery, you’d ideally do a session within 0–24 hours after exercise. It’s recommended that sessions be repeated several times in the same day or multiple times over a number of weeks.


Cryotherapy vs. Cryosurgery vs. Cryoablation

  • Cryotherapy, cryosurgery and cryoablation are sometimes used interchangeably to describe the use of very cold temperatures to destroy harmful cells. Usually the term “cryosurgery” is reserved for cryotherapy that involves surgery.  Whole-body cryotherapy does not involve surgery and does not require a doctor or medical procedure. Whole-body cryotherapy is therefore distinguished from “localized cryotherapy” because localized is more of an accepted medical practice that has been studied extensively.
  • Cryosurgery is surgery using the local application of intense cold to destroy unwanted tissue. Extreme cold is produced by liquid nitrogen (or argon gas).
  • Uses of cryosurgery/cryoablation include treating: pre-cancerous skin moles, nodules, skin tags, unsightly freckles, retinoblastomas (cancer of the retina in the eyes),atrial fibrillation (a type of heart rhythm disorder), and tumors in the prostate, liver, breasts, cervix, kidneys, lungs and bones.
  • The most common use of cryosurgery is removing external and internal tumors, including those on the skin or inside the body that may be cancerous. Liquid nitrogen is applied directly to external tumors with a cotton swab or spraying device that causes the tissue the be destroyed.
  • Cryosurgery is the surgical application of cryoablation inside the body. Cryoablation is performed using hollow needles called cryoprobes. Liquid nitrogen or argon gas is circulated through cryoprobes so it comes into contact with a tumor and freezes the abnormal cells. After cryosurgery the frozen tissue thaws and either dissolves or forms a scab.
  • Are there side effects associated with cryosurgery? Usually they are not severe and only temporary, but side effects may include: light bleeding, cramps, mild pain, swelling, blisters, redness, and rarely scarring or hair loss.

5 Potential Benefits of Cryotherapy

  1. Pain Reduction & Recovery From Injury

You’re probably already familiar with how cold packs and/or crushed ice provides effective short-term analgesia (pain relief) after injury or surgery. One of the most common reasons that people turn to cryotherapy is to prevent or treat muscle soreness after exercise, trauma or acute injuries.

A report published in Frontiers in Physiology states that “whole body cryotherapy is a medical physical treatment widely used in sports medicine. Recovery from injuries (e.g., trauma, overuse) and after-season recovery are the main purposes for application.” Athletes and people dealing with injuries often try cryotherapy hoping that it will be a preventive strategy for reducing the effects of exercise-induced inflammation and soreness.

A 2017 review that appeared in the International Journal of Sports Medicine, which included results from 16 eligible articles/studies, found evidence that cryotherapy helped reduce muscle pain (found in 80 percent of studies) and improved recovery in athletes and athletic capacity/performance (in 71 percent of studies). It also found that WBD didn’t cause side effects.

  1. Reduced Inflammation & Tissue Damage

The same review mentioned above also found evidence that cryotherapy benefits include reduction of systemic inflammation and lower concentrations of markers for muscle cell damage. (4) Overall, researchers involved in the review believe that cryotherapy can help improve recovery from muscle damage with multiple exposures. Multiple exposures were more likely to lead to improvements in recovery from pain, loss of muscle function, and markers of inflammation compared to single exposures/sessions.

Not every researcher/expert believes that cryotherapy works to fight inflammation. A 2014 review published in the Open Access Journal of Sports Medicine reports that “There is weak evidence from controlled studies that WBC enhances antioxidant capacity and parasympathetic reactivation, and alters inflammatory pathways relevant to sports recovery.” Researchers involved in this study believe that even though cryotherapy has tissue-cooling effects, the very cold air in the chambers is not effective as causing significant subcutaneous and core body cooling that is needed to fight inflammation. The conclusion of the review was that “athletes should remain cognizant that less expensive modes of cryotherapy, such as local ice-pack application or cold-water immersion, offer comparable physiological and clinical effects to WBC.”

Another recent review conducted by the School of Medicine at the University of Milan found observational evidence that WBC modifies many important biochemical and physiological parameters in human athletes. These include “a decrease in proinflammatory cytokines, adaptive changes in antioxidant status, and positive effects on muscular enzymes associated with muscle damage (creatine kinase and lactate dehydrogenase).”

  1. Mood Enhancement

What is the use of cryotherapy when it comes to improving your mental health? Proponents of cryotherapy say that the sudden drop in temperature once you’re inside the chamber helps to release mood-lifting endorphins, which make you feel happier and more energetic (just like when you finish exercising and feel a natural “high,” or when you take an ice cold shower to activate your brown fat).

WBC may make improve your mood because it counteracts pain, releases norepinephrine/adrenaline, facilitates mobilization and improves circulation. This seems plausible, but there hasn’t been much evidence proving it necessarily works for everyone.

  1. Improvements in Energy & Less Fatigue

Many people report feeling more clear-headed and energized following cryotherapy sessions. This is likely due to the release of endorphins, reduction in inflammation and increase in blood flow. There are some studies that have found WBC can enhance psychological recovery within days after a stressful event or hard workout, including decreasing perception of muscular tiredness, fatigue and pain for 24-48 hours following the session

  1. May Help Prevent Metabolic Disease

Because some studies have found that cryotherapy can help to reduce oxidative stress and inflammation, and to increase antioxidant status, it now being researched as a treatment method for preventing metabolic diseases, such as type 2 diabetes. In some ways, exposure to the cryotherapy mimics the effects of exercise since it positively impacts inflammatory pathways. One study that examined oxidative stress and antioxidant status in nonexercising participants found that those doing cryotherapy had an increase in antioxidant status associated in comparison to the untreated control group.

Other studies have found that cryotherapy may help to build the body’s defenses against the negative impact of stress (an underlying cause of many diseases) and support the nervous system. It’s been found that right after a cryotherapy session there is a significant increases in nor-epinephrine concentration compared to resting controls, similarly to what happens with exercise. But this ultimately has a positive effect on some important cellular and physiological events associated with inflammation.

When it comes to cryotherapy’s effects on the parasympathetic nervous system, which helps to calm the body after stress, studies have found that it has a large influence on parasympathetic reactivation, including improving heart-rate variability.

Can Cryotherapy Help With Weight Loss?

All over the internet people claim that cryotherapy can help improve your appearance and burn body fat. But studies haven’t shown there is any connection between cryotherapy and weight loss. One study showed that while exposure to cold can help regulate or slightly boost energy metabolism, six months of moderate aerobic activity combined with WBC did not change body mass, fat or lean body mass percentages in participants

That being said, if you find that cryotherapy helps to lift your mood, boost your energy, reduce pain and help you stay more active, then it may possibly support your weight loss goals indirectly.

Where to Get Cryotherapy

The best way to find a cryotherapy center in your area is to ask around for a referral— such as from your physical therapist, chiropractor or doctor— or search online, for example using the database on the US Cryotherapy website.

Depending on where you live, a whole-body cryotherapy session can cost somewhere in the range of $40-$100. Remember that sessions are typically very short, sometimes only a mere five minutes or less.

While cryotherapy does seem to be safe for most people overall, you should be careful about which center you choose to visit in order to reduce your risk for side effects. Make sure you visit a reputable center that is licensed and operated by knowledgable staff. Discuss any concerns you may have beforehand, and even consider asking your doctor for advice or a recommendation first if you’re unsure.

For cryosurgery treatments, ask your doctor for a recommendation or speak with your dermatologist. The type of medical professional you work with will depend on the goal of the treatment and condition being treated.


Is cryotherapy definitely safe? What risk might be involved?

There’s still some debate over whether cryotherapy machines are safe for the public. Overall most studies and reviews have found that there are no adverse events associated with WBC.

While it’s only happened very rarely, deaths have been reported that have been linked to cryotherapy. For example, in 2015 The New York Times reported about a woman in Nevada who passed away following a full-body cryotherapy session. In other states within the U.S., people have filed lawsuits claiming that cryotherapy has caused injuries including frost bite, third degree burns and dibilliations. This has promoted government officials to further investigate the safety of cryotherapy centers.

In certain situations WBC may not be safe. Contraindications of cryotherapy can include: uncontrolled hypertension, serious coronary disease, arrhythmia, circulatory disorders, Raynaud’s phenomenon (white fingers), cold allergies, serious pulmonary disease or the obstruction of the bronchus caused by a cold.

Final Thoughts on Cryotherapy

  • Cryotherapy is a treatment that involves exposure to extremely cold air. It is used to reduce inflammation, destroy damaged tissue/cells, release endorphins and improve circulation.
  • “Whole-body cryotherapy” involves a single or repeated exposure to extremely cold, dry air inside a special chamber or cabin for about 2–5 minutes. Cryotherapy chambers become extremely cold, dropping as low as minus 100 to minus 300 degrees Fahrenheit.
  • At this time there is mixed opinions regarding the evidence showing that cryotherapy helps to treat symptoms like pain, soreness and poor recovery from exercise. Cryotherapy has not been shown in clinical studies to burn fat or cause weight loss.
  • Potential benefits of cryotherapy according to some studies include: reduced pain and soreness, improved exercise recovery, mood enhancement, increased energy, and protection against metabolic diseases.
  • Cryotherapy is generally safe and tends not to cause adverse effects, although in rare cases frostbite, burns and even death have occurred.

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Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation.

Nowadays, whole-body cryotherapy is amedical physical treatment widely used in sports medicine. Recovery from injuries (e.g., trauma, overuse) and after-season recovery are the main purposes for application. However, the most recent studies confirmed the anti-inflammatory, anti-analgesic, and anti-oxidant effects of this therapy by highlighting the underlying physiological responses. In addition to its therapeutic effects, whole-body cryotherapy has been demonstrated to be a preventive strategy against the deleterious effects of exercise-induced inflammation and soreness. Novel findings have stressed the importance of fat mass on cooling effectiveness and of the starting fitness level on the final result. Exposure to the cryotherapy somehow mimics exercise, since it affects myokines expression in an exercise-like fashion, thus opening another possible window on the therapeutic strategies for metabolic diseases such as obesity and type 2 diabetes. From a biochemical point of view, whole-body cryotherapy not always induces appreciable modifications, but the final clinical output (in terms of pain, soreness, stress, and post-exercise recovery) is very often improved compared to either the starting condition or the untreated matched group. Also, the number and the frequency of sessions that should be applied in order to obtain the best therapeutic results have been deeply investigated in the last years. In this article, we reviewed the most recent literature, from 2010 until present, in order to give the most updated insight into this therapeutic strategy, whose rapidly increasing use is not always based on scientific assumptions and safety standards.

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Supportive Cryotherapy: A Review From Head to Toe

Conventional chemotherapy leads to adverse mucocutaneous complications such as oral mucositis (OM), alopecia, onycholysis, and 5- fluorouracil (5FU)-related ocular toxicity. Despite extensive research, limited pharmacologic interventions are available for preventing these clinical problems. Cryotherapy uses the basic principle that cold-induced vasoconstriction can limit the local effects of certain cytotoxic therapies. This review critically appraises the role of cryotherapy in supportive oncology, focusing on the prevention of these four chemotherapyinduced complications.

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